Papilledema is related to optic papillitis and intracranial hypertension, and has symptoms including edema An important gene associated with Papilledema is F2 (Coagulation Factor II, Thrombin), and among its related pathways/superpathways are Innate Immune System and Response to elevated platelet cytosolic Ca2+. The drugs Lymecycline and Doxycycline have been mentioned in the context of this disorder. Affiliated tissues include eye and brain, and related phenotypes are nervous system and homeostasis/metabolism