Pompholyx

Pompholyx, also known as vesicular eczema of hands and/or feet, is related to pemphigoid and anhidrosis, and has symptoms including pruritis and pustular rash. An important gene associated with Pompholyx is AQP10 (Aquaporin 10), and among its related pathways/superpathways are Hair follicle development: organogenesis - part 2 of 3 and EDA signaling in hair follicle development. The drugs Alitretinoin and Isotretinoin have been mentioned in the context of this disorder. Affiliated tissues include skin and subthalamic nucleus, and related phenotypes are pigmentation and craniofacial