Polyposis Syndrome, Hereditary Mixed, 1 (HMPS1)

Polyposis Syndrome, Hereditary Mixed, 1, also known as colorectal cancer, susceptibility to, 4, is related to hereditary mixed polyposis syndrome and rectum cancer. An important gene associated with Polyposis Syndrome, Hereditary Mixed, 1 is GREM1 (Gremlin 1, DAN Family BMP Antagonist), and among its related pathways/superpathways are Infectious disease and Homology Directed Repair. The drugs Clarithromycin and Cytochrome P-450 CYP3A Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include colon and eye, and related phenotypes are abnormal abdomen morphology and Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation