Polyposis, Skin Pigmentation, Alopecia, and Fingernail Changes

Polyposis, Skin Pigmentation, Alopecia, and Fingernail Changes, also known as cronkhite-canada syndrome, is related to protein-losing enteropathy and nutritional deficiency disease, and has symptoms including abdominal pain, cachexia and diarrhea. An important gene associated with Polyposis, Skin Pigmentation, Alopecia, and Fingernail Changes is TMEM247 (Transmembrane Protein 247), and among its related pathways/superpathways are Proton Pump Inhibitor Pathway, Pharmacodynamics and Secretion of hydrochloric acid in parietal cells. Affiliated tissues include skin and colon, and related phenotypes are malabsorption and hypoplastic toenails