Polysubstance Abuse, also known as drug addiction, is related to withdrawal disorder and substance abuse. An important gene associated with Polysubstance Abuse is FAAH (Fatty Acid Amide Hydrolase), and among its related pathways/superpathways are 22q11.2 copy number variation syndrome and Monoamine GPCRs. The drugs Ketamine and Lidocaine have been mentioned in the context of this disorder. Affiliated tissues include prefrontal cortex and brain, and related phenotypes are nervous system and behavior/neurological