Polyclonal Hypergammaglobulinemia, also known as polyclonal gammopathy, is related to histiocytosis-lymphadenopathy plus syndrome and angioimmunoblastic t-cell lymphoma. An important gene associated with Polyclonal Hypergammaglobulinemia is IL6 (Interleukin 6), and among its related pathways/superpathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. The drug Immunoglobulins has been mentioned in the context of this disorder. Affiliated tissues include lymph node and bone marrow, and related phenotypes are immune system and hematopoietic system