Pleural Disease, also known as non-neoplastic pleural disorder, is related to malignant pleural mesothelioma and asbestosis, and has symptoms including apnea, pleuritic pain and coughing. An important gene associated with Pleural Disease is ADA (Adenosine Deaminase), and among its related pathways/superpathways are MicroRNAs in cardiomyocyte hypertrophy and Cell differentiation - expanded index. The drugs Lidocaine and Neostigmine have been mentioned in the context of this disorder. Affiliated tissues include lung and heart.