Palmoplantar Keratoderma-Spastic Paralysis Syndrome, also known as palmoplantar hyperkeratosis-spastic paralysis syndrome, is related to keratoderma, palmoplantar, with nail dystrophy and hereditary motor-sensory neuropathy, and has symptoms including muscle spasticity Affiliated tissues include skin, and related phenotypes are gait disturbance and palmoplantar keratoderma