Palmoplantar Hyperkeratosis with Squamous Cell Carcinoma of Skin and 46,xx Sex Reversal, is also known as palmoplantar hyperkeratosis and true hermaphroditism. An important gene associated with Palmoplantar Hyperkeratosis with Squamous Cell Carcinoma of Skin and 46,xx Sex Reversal is RSPO1 (R-Spondin 1). Affiliated tissues include skin, and related phenotypes are palmoplantar keratoderma and squamous cell carcinoma of the skin