Pulmonary Disease, Chronic Obstructive, also known as chronic obstructive pulmonary disease, is related to respiratory failure and alpha-1-antitrypsin deficiency, and has symptoms including coughing, fever and pruritus. An important gene associated with Pulmonary Disease, Chronic Obstructive is SERPINA1 (Serpin Family A Member 1), and among its related pathways/superpathways are Interleukin-4 and Interleukin-13 signaling and Matrix metalloproteinases. The drugs Voriconazole and Benzylpenicillin have been mentioned in the context of this disorder. Affiliated tissues include lung and bone marrow, and related phenotype is chronic pulmonary obstruction.