Pulmonary Hypertension, Primary, 2, also known as pph2, is related to pulmonary hypertension, primary, 3 and turner syndrome. An important gene associated with Pulmonary Hypertension, Primary, 2 is SMAD9 (SMAD Family Member 9). The drugs Spironolactone and Mineralocorticoid Receptor Antagonists have been mentioned in the context of this disorder. Affiliated tissues include endothelial and heart, and related phenotypes are increased pulmonary vascular resistance and pulmonary arterial hypertension