Plagiocephaly, also known as lateral curvatures of skull unequal, is related to muenke syndrome and hemifacial hyperplasia. An important gene associated with Plagiocephaly is SMAD6 (SMAD Family Member 6), and among its related pathways/superpathways are PIP3 activates AKT signaling and Phospholipase-C Pathway. The drugs Salicylic acid and Date Palm have been mentioned in the context of this disorder. Affiliated tissues include brain and bone, and related phenotypes are normal and muscle