Placenta Disease

Placenta Disease, also known as pregnancy complications, is related to antiphospholipid syndrome and placenta accreta, and has symptoms including morning sickness, hyperemesis gravidarum and late pregnancy bleeding. An important gene associated with Placenta Disease is PAPPA (Pappalysin 1), and among its related pathways/superpathways are Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) and Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors. The drugs Metronidazole and Sulfadoxine have been mentioned in the context of this disorder. Affiliated tissues include placenta and heart, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance