Placental Insufficiency, also known as uteroplacental vascular insufficiency, is related to antiphospholipid syndrome and persistent fetal circulation syndrome. An important gene associated with Placental Insufficiency is PGF (Placental Growth Factor), and among its related pathways/superpathways are ERK Signaling and MIF Mediated Glucocorticoid Regulation. The drugs Acetylsalicylic acid and Benzocaine have been mentioned in the context of this disorder. Affiliated tissues include placenta and heart, and related phenotypes are abnormal placenta morphology and intrauterine growth retardation