Paget Disease of Bone 3 (PDB3)

Paget Disease of Bone 3, also known as osteitis deformans, is related to paget's disease of bone and paget disease of bone 5, juvenile-onset, and has symptoms including back pain, muscle cramp and sciatica. An important gene associated with Paget Disease of Bone 3 is SQSTM1 (Sequestosome 1). The drugs Zoledronic acid and Pamidronic acid have been mentioned in the context of this disorder. Affiliated tissues include bone and spinal cord, and related phenotypes are hearing impairment and osteosarcoma