Ovarian Disease, also known as ovarian dysfunction, is related to polycystic ovary syndrome and estrogen excess, and has symptoms including pelvic pain and mittelschmerz. An important gene associated with Ovarian Disease is SHBG (Sex Hormone Binding Globulin), and among its related pathways/superpathways are Metabolism of steroid hormones and Prader-Willi and Angelman syndrome. The drugs Polyestradiol phosphate and Estradiol have been mentioned in the context of this disorder. Affiliated tissues include ovary and uterus, and related phenotypes are endocrine/exocrine gland and reproductive system