Ossification of the Posterior Longitudinal Ligament of Spine (OPLL)

Ossification of the Posterior Longitudinal Ligament of Spine, also known as ossification of the posterior longitudinal ligament of the spine, is related to exostosis and spinal disease. An important gene associated with Ossification of the Posterior Longitudinal Ligament of Spine is ENPP1 (Ectonucleotide Pyrophosphatase/Phosphodiesterase 1), and among its related pathways/superpathways are Phospholipase-C Pathway and Clock-controlled autophagy in bone metabolism. Affiliated tissues include spinal cord and bone, and related phenotypes are hyperreflexia and diabetes mellitus