Osseous Heteroplasia, Progressive (POH)

Osseous Heteroplasia, Progressive, also known as progressive osseous heteroplasia, is related to myositis ossificans and ossification of the posterior longitudinal ligament of spine, and has symptoms including polydipsia and muscle weakness. An important gene associated with Osseous Heteroplasia, Progressive is GNAS (GNAS Complex Locus), and among its related pathways/superpathways are Signal Transduction and ADORA2B mediated anti-inflammatory cytokines production. The drugs Etoricoxib and Pharmaceutical Solutions have been mentioned in the context of this disorder. Affiliated tissues include bone and skin, and related phenotypes are subcutaneous nodule and limitation of joint mobility