Orbital Disease, also known as orbit, is related to graves disease 1 and graves ophthalmopathy, and has symptoms including eye manifestations and visual disturbance. An important gene associated with Orbital Disease is TSHR (Thyroid Stimulating Hormone Receptor), and among its related pathways/superpathways are Innate Immune System and Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. The drugs Ciprofloxacin and Cytochrome P-450 Enzyme Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include eye and ciliary ganglion, and related phenotypes are immune system and hematopoietic system