Optic Nerve Disease, also known as optic neuropathy, is related to leber optic atrophy and dystonia and toxic optic neuropathy, and has symptoms including eye manifestations and sciatica. An important gene associated with Optic Nerve Disease is TYR (Tyrosinase), and among its related pathways/superpathways are Metabolism and Glucose / Energy Metabolism. The drugs Acetazolamide and Bevacizumab have been mentioned in the context of this disorder. Affiliated tissues include eye and retina, and related phenotype is vision/eye.