Neurofibromatosis, Type I, also known as von recklinghausen disease, is related to neurofibroma and legius syndrome, and has symptoms including neuralgia An important gene associated with Neurofibromatosis, Type I is NF1 (Neurofibromin 1), and among its related pathways/superpathways are Signal Transduction and Neuroscience. The drugs Dopamine and Methylphenidate have been mentioned in the context of this disorder. Affiliated tissues include skin and bone, and related phenotypes are hypertelorism and delayed puberty