Neurodegeneration with Brain Iron Accumulation 2a (NBIA2A)

Neurodegeneration with Brain Iron Accumulation 2a, also known as infantile neuroaxonal dystrophy, is related to spastic quadriplegic cerebral palsy and dementia, and has symptoms including ataxia, seizures and abnormal pyramidal signs. An important gene associated with Neurodegeneration with Brain Iron Accumulation 2a is PLA2G6 (Phospholipase A2 Group VI), and among its related pathways/superpathways are Metabolism and Metabolism of water-soluble vitamins and cofactors. The drugs Desipramine and Neurotransmitter Agents have been mentioned in the context of this disorder. Affiliated tissues include brain and eye, and related phenotypes are developmental regression and cerebellar atrophy