Nontoxic Goiter, also known as retrosternal thyroid struma, is related to goiter, multinodular 1, with or without sertoli-leydig cell tumors and hypothyroidism, congenital, nongoitrous, 2. An important gene associated with Nontoxic Goiter is TG (Thyroglobulin), and among its related pathways/superpathways are Transcription_Role of VDR in regulation of genes involved in osteoporosis and Development_Hedgehog and PTH signaling pathways in bone and cartilage development. The drugs Methimazole and Hormone Antagonists have been mentioned in the context of this disorder. Affiliated tissues include thyroid and pituitary, and related phenotypes are Increased shRNA abundance (Z-score > 2) and endocrine/exocrine gland