Non-Specific Early-Onset Epileptic Encephalopathy

Non-Specific Early-Onset Epileptic Encephalopathy, also known as undetermined early-onset epileptic encephalopathy, is related to familial or sporadic hemiplegic migraine and cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 2. An important gene associated with Non-Specific Early-Onset Epileptic Encephalopathy is IQSEC2 (IQ Motif And Sec7 Domain ArfGEF 2), and among its related pathways/superpathways are Presenilin-Mediated Signaling and Fc-GammaR Pathway. Affiliated tissues include brain and eye, and related phenotypes are encephalopathy and intellectual disability