Non-Progressive Predominantly Posterior Cavitating Leukoencephalopathy with Peripheral Neuropathy An important gene associated with Non-Progressive Predominantly Posterior Cavitating Leukoencephalopathy with Peripheral Neuropathy is COA8 (Cytochrome C Oxidase Assembly Factor 8). Affiliated tissues include brain and skeletal muscle, and related phenotypes are progressive peripheral neuropathy and progressive leukoencephalopathy