Ngly1-Deficiency

Ngly1-Deficiency, also known as congenital disorder of glycosylation type iv, is related to hypotonia and microcephaly. An important gene associated with Ngly1-Deficiency is NGLY1 (N-Glycanase 1), and among its related pathways/superpathways are Metabolism of proteins and Transport to the Golgi and subsequent modification. The drug Ophthalmic Solutions has been mentioned in the context of this disorder. Affiliated tissues include liver, and related phenotypes are Decreased shRNA abundance and mortality/aging