Necrotizing Fasciitis, also known as fasciitis, necrotizing, is related to fasciitis and mediastinitis, and has symptoms including spasm and generalized muscle weakness. An important gene associated with Necrotizing Fasciitis is MYOM2 (Myomesin 2), and among its related pathways/superpathways are IL-1 Family Signaling Pathways and Immune response IL-23 signaling pathway. The drugs gamma-Globulins and Immunoglobulin G have been mentioned in the context of this disorder. Affiliated tissues include skin and neutrophil, and related phenotypes are cardiovascular system and immune system