Mitral Valve Disease, also known as chronic rheumatic mitral valve, is related to mitral valve stenosis and orthostatic intolerance. An important gene associated with Mitral Valve Disease is NPPA (Natriuretic Peptide A), and among its related pathways/superpathways are Peptide hormone metabolism and MicroRNAs in cardiomyocyte hypertrophy. The drugs Acetaminophen and Ropivacaine have been mentioned in the context of this disorder. Affiliated tissues include heart and whole blood, and related phenotypes are homeostasis/metabolism and muscle