Mitral Valve Insufficiency, also known as mitral regurgitation, is related to cardiomyopathy, familial hypertrophic, 1 and angina pectoris. An important gene associated with Mitral Valve Insufficiency is TBX5 (T-Box Transcription Factor 5), and among its related pathways/superpathways are Cardiac conduction and Embryonic and Induced Pluripotent Stem Cells and Lineage-specific Markers. The drugs Ranolazine and Hydrocortisone have been mentioned in the context of this disorder. Affiliated tissues include heart and brain, and related phenotypes are muscle and renal/urinary system