Methemoglobinemia is related to congenital methemoglobinemia and acquired methemoglobinemia, and has symptoms including cyanosis An important gene associated with Methemoglobinemia is CYB5R3 (Cytochrome B5 Reductase 3), and among its related pathways/superpathways are Metabolism and Metapathway biotransformation Phase I and II. The drugs Methylene blue and Enzyme Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include heart and skin, and related phenotype is Decreased shRNA abundance.