Mitochondrial Dna Depletion Syndrome 16b, also known as mtdps16b, is related to acute liver failure and progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal dominant 4. An important gene associated with Mitochondrial Dna Depletion Syndrome 16b is POLG2 (DNA Polymerase Gamma 2, Accessory Subunit). Affiliated tissues include liver, and related phenotypes are depression and ataxia