Metabolic Crises, Recurrent, with Rhabdomyolysis, Cardiac Arrhythmias, and Neurodegeneration (MECRCN)

Metabolic Crises, Recurrent, with Rhabdomyolysis, Cardiac Arrhythmias, and Neurodegeneration, also known as recurrent metabolic encephalomyopathic crises-rhabdomyolysis-cardiac arrhythmia-intellectual disability syndrome, is related to tango2-related metabolic encephalopathy and arrythmias and recurrent metabolic encephalomyopathic crises-rhabdomyolysis-cardiac arrhythmia-, and has symptoms including muscle cramp, muscle rigidity and muscle spasticity. An important gene associated with Metabolic Crises, Recurrent, with Rhabdomyolysis, Cardiac Arrhythmias, and Neurodegeneration is TANGO2 (Transport And Golgi Organization 2 Homolog). The drugs Propofol and Sevoflurane have been mentioned in the context of this disorder. Affiliated tissues include skeletal muscle and brain, and related phenotypes are intellectual disability and global developmental delay