Mandibular Hypoplasia, Deafness, Progeroid Features, and Lipodystrophy Syndrome (MDPL)

Mandibular Hypoplasia, Deafness, Progeroid Features, and Lipodystrophy Syndrome, also known as mdp syndrome, is related to hutchinson-gilford progeria syndrome and werner syndrome, and has symptoms including decreased adipose tissue An important gene associated with Mandibular Hypoplasia, Deafness, Progeroid Features, and Lipodystrophy Syndrome is POLD1 (DNA Polymerase Delta 1, Catalytic Subunit), and among its related pathways/superpathways are Glucose / Energy Metabolism and Mesenchymal Stem Cells and Lineage-specific Markers. The drugs Insulin glulisine and Zinc cation have been mentioned in the context of this disorder. Affiliated tissues include skin and skeletal muscle, and related phenotypes are sensorineural hearing impairment and cryptorchidism