Multiple Endocrine Neoplasia, Type Iib (MEN2B)

Multiple Endocrine Neoplasia, Type Iib, also known as multiple endocrine neoplasia type 2b, is related to neuroma and intestinal obstruction, and has symptoms including constipation and diarrhea. An important gene associated with Multiple Endocrine Neoplasia, Type Iib is RET (Ret Proto-Oncogene), and among its related pathways/superpathways are Signal Transduction and RAF/MAP kinase cascade. The drugs Sorafenib and Protein Kinase Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include thyroid and tongue, and related phenotypes are scoliosis and constipation