Multicentric Carpotarsal Osteolysis Syndrome (MCTO)

Alias:

Multicentric Carpo-Tarsal Osteolysis with or Without Nephropathy

Osteolysis, Hereditary, of Carpal Bones with or Without Nephropathy

Mcto

Hereditary Osteolysis of Carpal Bones with or Without Nephropathy

Idiopathic Multicentric Osteolysis with or Without Nephropathy

Autosomal Dominant Multicentric Osteolysis

Multicentric Osteolysis Nephropathy

Osteolysis, Carpotarsal, Multicentric Syndrome

Multicentric Osteolysis, Autosomal Dominant

Lytic Lesion

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Basic Information

Medical Symptom

Gene & Mutation

Related Drugs

Disease Model

References Literature

Multicentric Carpotarsal Osteolysis Syndrome, also known as multicentric carpo-tarsal osteolysis with or without nephropathy, is related to arthropathy and osteochondrodysplasia, and has symptoms including wrist pain and ankle pain. An important gene associated with Multicentric Carpotarsal Osteolysis Syndrome is MAFB (MAF BZIP Transcription Factor B), and among its related pathways/superpathways are Vitamin D receptor pathway and Tacrolimus/Cyclosporine Pathway, Pharmacodynamics. Affiliated tissues include bone and kidney, and related phenotypes are gait disturbance and proteinuria

Related ID：

MALACARDS：MLT092

OMIM：166300

MESH：C567171