Melanoma-Astrocytoma Syndrome, also known as melanoma and neural system tumor syndrome, is related to diffuse astrocytoma and skin melanoma. An important gene associated with Melanoma-Astrocytoma Syndrome is CDKN2A (Cyclin Dependent Kinase Inhibitor 2A), and among its related pathways/superpathways is Oncogene Induced Senescence. Affiliated tissues include spinal cord and skin, and related phenotypes are astrocytoma and cutaneous melanoma