Male Infertility Due to Large-Headed Multiflagellar Polyploid Spermatozoa, also known as male infertility due to macrozoospermia, is related to spermatogenic failure 5 and polyploidy. An important gene associated with Male Infertility Due to Large-Headed Multiflagellar Polyploid Spermatozoa is AKAP3 (A-Kinase Anchoring Protein 3). Related phenotypes are cellular and reproductive system