Melnick-Needles Syndrome (MNS)

Melnick-Needles Syndrome, also known as melnick-needles osteodysplasty, is related to otopalatodigital syndrome, type i and frank-ter haar syndrome, and has symptoms including hoarseness An important gene associated with Melnick-Needles Syndrome is FLNA (Filamin A), and among its related pathways/superpathways are Cytoskeletal Signaling and MAPK signaling pathway. The drugs Valproic acid and Angiotensin II have been mentioned in the context of this disorder. Affiliated tissues include bone and eye, and related phenotypes are hypertelorism and prominent supraorbital ridges