Malignant Migrating Focal Seizures of Infancy (MPEI)

Malignant Migrating Focal Seizures of Infancy, also known as malignant migrating partial seizures of infancy, is related to developmental and epileptic encephalopathy 14 and epilepsy, and has symptoms including clonus and twitching of facial muscles. An important gene associated with Malignant Migrating Focal Seizures of Infancy is KCNT1 (Potassium Sodium-Activated Channel Subfamily T Member 1), and among its related pathways/superpathways are G-Beta Gamma Signaling and Neuropathic Pain-Signaling in Dorsal Horn Neurons. Affiliated tissues include brain and tongue, and related phenotypes are developmental regression and cognitive impairment