Malignant Hyperthermia 5, also known as malignant hyperthermia, susceptibility to, 5, is related to malignant hyperthermia and hypokalemic periodic paralysis, type 1. An important gene associated with Malignant Hyperthermia 5 is CACNA1S (Calcium Voltage-Gated Channel Subunit Alpha1 S). Affiliated tissues include skeletal muscle and heart, and related phenotypes are fever and malignant hyperthermia