Malignant Hyperthermia Susceptibility, also known as malignant hyperpyrexia due to anesthesia, is related to malignant hyperthermia 1 and neuromuscular disease, and has symptoms including fever, muscle rigidity and pain, postoperative. An important gene associated with Malignant Hyperthermia Susceptibility is RYR1 (Ryanodine Receptor 1), and among its related pathways/superpathways are DREAM Repression and Dynorphin Expression and Myometrial relaxation and contraction pathways. Affiliated tissues include skeletal muscle and smooth muscle.