Malignant Hyperthermia (MHS)

Malignant Hyperthermia, also known as anesthesia related hyperthermia, is related to malignant hyperthermia 1 and congenital myopathy 13, and has symptoms including fever, muscle rigidity and pain, postoperative. An important gene associated with Malignant Hyperthermia is RYR1 (Ryanodine Receptor 1), and among its related pathways/superpathways are CREB Pathway and Cardiac conduction. The drugs Halothane and Caffeine have been mentioned in the context of this disorder. Affiliated tissues include skeletal muscle and heart, and related phenotypes are muscle and homeostasis/metabolism