Malignant Syringoma

Malignant Syringoma, also known as microcystic adnexal carcinoma, is related to skin benign neoplasm and morpheaform basal cell carcinoma. An important gene associated with Malignant Syringoma is PHLDA1 (Pleckstrin Homology Like Domain Family A Member 1), and among its related pathways/superpathways are COPI-independent Golgi-to-ER retrograde traffic and Cytoskeletal Signaling. The drugs Talimogene laherparepvec and Nivolumab have been mentioned in the context of this disorder. Affiliated tissues include skin and bone marrow, and related phenotype is digestive/alimentary.