Malignant Acrospiroma, also known as eccrine ductal carcinoma, is related to eyelid carcinoma and malignant syringoma. An important gene associated with Malignant Acrospiroma is PHLDA1 (Pleckstrin Homology Like Domain Family A Member 1). The drugs Talimogene laherparepvec and Nivolumab have been mentioned in the context of this disorder. Affiliated tissues include skin.