Mal De Meleda (MDM)

Mal De Meleda, also known as meleda disease, is related to palmoplantar keratosis and palmoplantar keratoderma, nagashima type. An important gene associated with Mal De Meleda is SLURP1 (Secreted LY6/PLAUR Domain Containing 1), and among its related pathways/superpathways are Post-translational modification: synthesis of GPI-anchored proteins and Burn wound healing. Affiliated tissues include skin and heart, and related phenotypes are palmoplantar keratoderma and abnormality of the hand