Mikulicz Disease, also known as igg4-related dacryoadenitis and sialadenitis, is related to thyroiditis and chronic rhinitis, and has symptoms including lumps of the face An important gene associated with Mikulicz Disease is IL4 (Interleukin 4), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. Affiliated tissues include eye and salivary gland, and related phenotypes are abnormal salivary gland morphology and enlarged lacrimal glands