Major Affective Disorder 8, also known as major affective disorder-8, susceptibility to, is related to major affective disorder 1 and bipolar disorder. An important gene associated with Major Affective Disorder 8 is MAFD8 (Major Affective Disorder-8, Susceptibility To). The drugs Asenapine and Risperidone have been mentioned in the context of this disorder. Affiliated tissues include brain and prefrontal cortex.