Megalencephalic Leukoencephalopathy with Subcortical Cysts 2b, Remitting, with or Without Impaired Intellectual Development, also known as mlc2b, is related to megalencephalic leukoencephalopathy with subcortical cysts 2a. An important gene associated with Megalencephalic Leukoencephalopathy with Subcortical Cysts 2b, Remitting, with or Without Impaired Intellectual Development is HEPACAM (Hepatic And Glial Cell Adhesion Molecule). Affiliated tissues include brain and cerebellum.