Mediastinal Gray Zone Lymphoma, also known as mediastinal b-cell lymphoma, unclassifiable, with features intermediate between diffuse large b-cell lymphoma and classical hodgkin lymphoma, is related to lymphoma, hodgkin, classic and b-cell lymphoma. An important gene associated with Mediastinal Gray Zone Lymphoma is TNFRSF8 (TNF Receptor Superfamily Member 8), and among its related pathways/superpathways are NF-kappaB Signaling and Extrafollicular and follicular B cell activation by SARS-CoV-2. Related phenotypes are Increased shRNA abundance (Z-score > 2) and immune system