Middle Ear Disease, also known as disorder of middle ear, is related to mastoiditis and otorrhea. An important gene associated with Middle Ear Disease is CBS (Cystathionine Beta-Synthase), and among its related pathways/superpathways are Innate Immune System and Immune response IL-23 signaling pathway. The drugs Oxymetazoline and Histamine have been mentioned in the context of this disorder. Affiliated tissues include bone and brain, and related phenotypes are homeostasis/metabolism and immune system